How COX-2 inhibitors increase the risk of heart disease and stroke

The evidence showing a strong association between selective COX-2 inhibition (from Vioxx™, Bextra™, or Celebrex™) and risk of heart disease and stroke has been piling on ever since Vioxx™ was removed from the market in the fall of last year. Now, we have studies that get into the nitty-gritty of exactly “_how_ COX-2 inhibitors do this”: This is useful information because it might lead to clinical tests that help determine the risk-benefit balance of going on COX-2 medication and might even inform dosage.

Personally, I’ll stay away from the stuff.

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